Warfarin Sodium Clathrate CAS NO 51821-81-9 Inquire about Warfarin Sodium Clathrate 

Tecoland supplies Warfarin Sodium Clathrate bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Warfarin Sodium Clathrate is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Warfarin Sodium Clathrate

Warfarin sodium clathrate is a small-molecule drug that acts as an anticoagulant by inhibiting the synthesis of vitamin K-dependent clotting factors. Warfarin sodium clathrate is used to prevent and treat deep vein thrombosis, pulmonary embolism, and other conditions. Warfarin sodium clathrate interacts with a number of drugs, including those that are used to treat high blood pressure, depression, or heart disease. The molecular weight of warfarin sodium clathrate is 594.5 grams per mole. This drug has been shown to be effective in treating autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. It has also been shown to have some clinical relevance for atrial fibrillation patients who have chronic oral anticoagulation therapy. A specific antidote for warfarin sodium clathrate overdose is available in the form of heparin (a low molecular weight heparin).

Warnings

You should not take warfarin if you are prone to bleeding because of a medical condition, if you have an upcoming surgery, or if you need a spinal tap or epidural. Do not take warfarin if you cannot take it on time every day.

Warfarin increases your risk of severe or fatal bleeding, especially if you have certain medical conditions, if you are 65 or older, or if you have had a stroke, or bleeding in your stomach or intestines. Seek emergency help if you have any bleeding that will not stop.

Call your doctor at once if you have other signs of bleeding such as: swelling, pain, feeling very weak or dizzy, unusual bruising, bleeding gums, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Many other drugs can increase your risk of bleeding when used with warfarin. Tell your doctor about all medicines you have recently used.

Avoid making any changes in your diet without first talking to your doctor. Some foods can make warfarin less effective.

Before taking this medicine

You should not take warfarin if you are allergic to it, or if:

  • you have very high blood pressure;
  • you recently had or will have surgery on your brain, spine, or eye;
  • you undergo a spinal tap or spinal anesthesia (epidural); or
  • you cannot take warfarin on time every day.

You also should not take this medicine if you are prone to bleeding because of a medical condition, such as:

  • a blood cell disorder (such as low red blood cells or low platelets);
  • ulcers or bleeding in your stomach, intestines, lungs, or urinary tract;
  • an aneurysm or bleeding in the brain; or
  • an infection of the lining of your heart.

Do not take warfarin if you are pregnant, unless your doctor tells you to. Warfarin can cause birth defects, but preventing blood clots may outweigh any risks to the baby. If you are not pregnant, use effective birth control to prevent pregnancy while taking warfarin and for at least 1 month after your last dose. Tell your doctor right away if you become pregnant.

Warfarin can make you bleed more easily, especially if you have ever had:

  • high blood pressure or serious heart disease;
  • kidney disease;
  • cancer or low blood cell counts;
  • an accident or surgery;
  • bleeding in your stomach or intestines;
  • a stroke; or
  • if you are 65 or older.

To make sure warfarin is safe for you, tell your doctor if you have ever had:

  • diabetes;
  • congestive heart failure;
  • liver disease, kidney disease (or if you are on dialysis);
  • a hereditary clotting deficiency; or
  • low blood platelets after receiving heparin.

It is not known whether warfarin passes into breast milk. Watch for signs of bruising or bleeding in the baby if you take this medicine while you are breast-feeding a baby.

What to avoid

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. You may still bleed more easily for several days after you stop taking warfarin.

Avoid making any changes in your diet without first talking to your doctor. Foods that are high in vitamin K (liver, leafy green vegetables, or vegetable oils) can make warfarin less effective. If these foods are part of your diet, eat a consistent amount on a weekly basis.

Grapefruit juice, cranberry juice, noni juice, and pomegranate juice may interact with warfarin and lead to unwanted side effects. Avoid the use of these juice products while taking this medicine.

Avoid drinking alcohol.

Ask your doctor before using any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. These medicines may affect blood clotting and may also increase your risk of stomach bleeding.

Warfarin Side Effects

Get emergency medical help if you have signs of an allergic reaction to warfarin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Warfarin increases your risk of bleeding, which can be severe or life-threatening. Call your doctor at once if you have any signs of bleeding such as:

  • sudden headache, feeling very weak or dizzy;
  • swelling, pain, unusual bruising;
  • bleeding gums, nosebleeds;
  • bleeding from wounds or needle injections that will not stop;
  • heavy menstrual periods or abnormal vaginal bleeding;
  • blood in your urine, bloody or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Clots formed by warfarin may block normal blood flow, which could lead to tissue death or amputation of the affected body part. Get medical help at once if you have:

  • pain, swelling, hot or cold feeling, skin changes, or discoloration anywhere on your body; or
  • sudden and severe leg or foot pain, foot ulcer, purple toes or fingers.

Bleeding is the most common side effect of warfarin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Drug Interactions

Many drugs (including some over-the-counter medicines and herbal products) can affect your INR and may increase the risk of bleeding if you take them with warfarin. Not all possible drug interactions are listed in this medication guide. It is very important to ask your doctor and pharmacist before you start or stop using any other medicine, especially:

  • other medicines to prevent blood clots;
  • an antibiotic or antifungal medicine;
  • supplements that contain vitamin K; or
  • herbal (botanical) products – coenzyme Q10, cranberry, echinacea, garlic, ginkgo biloba, ginseng, goldenseal, or St. John’s wort.

This list is not complete and many other drugs can interact with warfarin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.