Virginiamycin CAS NO 11006-76-1 Inquire about Virginiamycin 

Tecoland supplies Virginiamycin bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Virginiamycin is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Virginiamycin?Virginiamycin_S1Virginiamycin

Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent microbial contamination and in livestock to prevent and treat infections. According to a USDA study, antibiotics can save as much as 30% in feed costs among young swine.

Broiler chickens
Table of approved claims and brands
Approved claims Name of
approved brand(s)		 Drug concentration in
DIN product
Claim 1 1. Stafac 22 Premix Virginiamycin at 22 g/kg
Claim 1 2. Stafac 44 Premix
3. Virginiamycin 44 Drug Premix		 Virginiamycin at 44 g/kg
Claim 1 4. Stafac 500 Premix Virginiamycin at 500 g/kg

Approved for use in meal and pellet feed

Claim 1

For the prevention of necrotic enteritis caused by Clostridium perfringens susceptible to virginiamycin.

Level of medicating ingredient in a complete feed

22 mg/kg (0.0022%) of virginiamycin in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

The medicated feed is to be fed continuously as the sole ration from day one to market weight.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 22 mg/kg (0.0022%) of virginiamycin per metric tonne (1000 kg) of finished (complete) feed:

  • 1.0 kg of the Stafac 22 Premix; or
  • 0.5 kg (500 g) of the Stafac 44 Premix or the Virginiamycin 44 Drug Premix; or
  • 0.044 kg (44 g) of the Stafac 500 Premix

Note: To ensure proper mixing, the virginiamycin premix should first be diluted in an intermediate blending step and be thoroughly mixed with a small quantity of feed ingredients prior to the manufacturing of the medicated feed.

Warning

  1. No withdrawal period is required when this medicated feed is fed at the recommended level of 22 mg/kg(0.0022%) virginiamycin in the complete feed.
  2. Do not feed to birds producing eggs for human consumption.
  3. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. (Required on premix and supplement labels only)
  4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Do not feed to replacement or breeding chickens.
  2. Do not use in feeds containing pellet-binding agents with the exception of bentonite, Pel-Aid, Agri-Colloid, and Lignosol. (Required on premix and supplement labels only)
  3. Do not feed undiluted. (Required on premix and supplement labels only)

Accepted compatibilities

Virginiamycin is compatible with the following drug/drug combinations. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Virginiamycin (broiler chickens)
Name of medicating ingredient MIB code Name of approved brand(s) Applicable claims
Semduramicin sodium SEMD Aviax Medicated Premix 5% All claims
Swine
Table of approved claims and brands
Approved claims Name of
approved brand(s)		 Drug concentration in
DIN product
Claim 1 1. Stafac 22 Premix Virginiamycin at 22 g/kg
Claim 1 2. Stafac 44 Premix
3. Virginiamycin 44 Drug Premix		 Virginiamycin at 44 g/kg
Claim 1 4. Stafac 500 Premix Virginiamycin at 500 g/kg

Approved for use in meal and pellet feed

Claim 1

For the treatment and control of swine dysentery.

Level of medicating ingredient in a complete feed

  1. 110 mg/kg(0.011%) of virginiamycin in the complete feed for the first 2 weeks, followed by
  2. 55 mg/kg(0.0055%) of virginiamycin in the complete feed for the next 4 weeks.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

  1. Feed 110 mg/kgmedicated feed as the sole ration for the first 2 weeks of treatment. This must be followed by 55 mg/kg medicated feed for the next 4 weeks.
  2. Feed 55 mg/kgmedicated feed as the sole ration for 4 weeks only after having fed 110 mg/kg medicated feed for 2 weeks.

Feed this medicated feed as the sole ration. If dysentery reoccurs, re-treat with the same regime.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 110 mg/kg (0.0011%) of virginiamycin per metric tonne (1000 kg) of finished (complete) feed:

  • 5.0 kg of the Stafac 22 Premix; or
  • 2.5 kg of the Stafac 44 Premix or the Virginiamycin 44 Drug Premix; or
  • 0.22 kg of the (220 g) Stafac 500 Premix

Add and thoroughly mix into the ration at the following rate to provide 55 mg/kg (0.0055%) of virginiamycin per metric tonne (1000 kg) of finished (complete) feed:

  • 2.5 kg of the Stafac 22 Premix; or
  • 1.25 kg Stafac 44 Premix or the Virginiamycin 44 Drug Premix; or
  • 0.11 kg (110 g) Stafac 500 Premix

Note: To ensure proper mixing, the virginiamycin premix should first be diluted in an intermediate blending step and be thoroughly mixed with a small quantity of feed ingredients prior to the manufacturing of the medicated feed.

Warning

  1. No withdrawal period is required when this medicated feed is fed at the recommended level of up to 110 mg/kg(0.011%) virginiamycin in the complete feed.
  2. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Do not use in feeds containing pellet-binding agents with the exception of bentonite, Pel-Aid, Agri-Colloid, and Lignosol.
  2. Do not feed undiluted. (Required on premix and supplement labels only)

Accepted Compatibilities

Nil

Cattle (fed in confinement for slaughter)
Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1 1.   V-Max 44 Virginiamycin Premix Virginiamycin at 44 g/kg
Claim 1 1.   V-Max 500 Virginiamycin Premix Virginiamycin at 500 g/kg

Approved for use in meal and pellet feed

Claim 1

For the reduction of the incidence of liver abscesses.

Level of medicating ingredient in a complete feed

20 mg/kg (0.002%) of virginiamycin in the complete feed

Directions for use in a complete feed

To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic only during periods of increased risk of ruminal acidosis, for the shortest duration required.

Feed this medicated feed continuously as the sole ration for up to 75 days.

Note required to appear on medicated feed labels
  • Due to the multifactorial approach needed to reduce the risk of liver abscesses, the management of the animals’ vaccination status, environment and nutrition should be optimized prior to or concurrently with antibiotic treatment.

Additional information (not to appear on feed labels)

For feed manufacturers
  • A concentration of 20 mg/kg (or 20 grams per 1000 kg of feed) of virginiamycin in the complete feed will provide 200 to 250 mg of virginiamycin/head/day, based on a daily intake of 10 to 12.5 kg of medicated complete feed/head/day

Add and thoroughly mix into the ration at the following rate to provide 20 mg/kg (0.002%) of virginiamycin per metric tonne (1000 kg) of finished (complete) feed:

  • 0.45 kg (450 g) of V-Max 44 Virginiamycin Premix
  • 0.04 kg (40 g) of V-Max 500 Virginiamycin Premix

Note: To ensure proper mixing, the virginiamycin premix should first be diluted in an intermediate blending step and be thoroughly mixed with a small quantity of feed ingredients prior to the manufacturing of the medicated feed.

Warning

  1. No withdrawal period is required when this medicated feed is fed at the recommended level of 20 mg/kg (0.002%) virginiamycin in the complete feed.
  2. Do not use in calves to be processed for veal. The withdrawal period has not been established in pre-ruminating calves.
  3. Do not use in lactating dairy cattle.
  4. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. (Required on premix and supplement labels only)
  5. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Not for use in pregnant or lactating females or animals intended for breeding.
  2. Do not feed undiluted. (Required on premix and supplement labels only)
Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.

External Link:
  1. Wikipedia contributors. (2021, January 14). Virginiamycin. In Wikipedia, The Free Encyclopedia. Retrieved 21:55, February 1, 2021, from https://en.wikipedia.org/w/index.php?title=Virginiamycin&oldid=1000309005
  2. Virginiamycin (VMY). (n.d.). Inspection.gc.ca.  https://www.inspection.gc.ca/animal-health/livestock-feeds/medicating-ingredients/mib/virginiamycin-vmy-/eng/1331059542163/1331059612134#shr-pg0