Tylosin CAS NO 1401-69-0 Inquire about Tylosin

Tecoland supplies Tylosin bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Tylosin is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Tylosin?

Tylosin is a coccidiostat food additive used in veterinary medicine. It has a broad spectrum of activity against gram positive organisms and a limited range of gram negative organisms. It is found naturally as a fermentation product of Streptomyces fradiae.

Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety. It has also been used as a growth promotant in some species, and as a treatment for colitis in companion animals.

Clinical Uses of Tylosin

Tylosin has been used to treat a variety of different diseases throughout the world. Differing formulations and licensing conditions will mean that it may not be a recognized method of treatment for certain conditions in certain countries. In general, tylosin is licensed for the treatment of infections caused by organisms susceptible to the drug, but it has also been used as a treatment of colitis in small animals, as a growth promotant in food producing animals, and as a way of reducing epiphora (tear staining) around the eyes of white faced dogs. In these cases, the resulte is positive only when using the tylosin in the form of tartrate, a chelating porphyrin. No marketing authority exists for the use of other tylosin forms as a tear stain remover and thus it is not legal to use it for such purposes- the exception being as a Prescription Only Medicine of last resort by vets under the Cascading Rule (UK) or the Extra Label rule (US).

Examples of bacterial infections that could potentially be treated with tylosin include respiratory infections, metritis, and acute mastitis in cattle; mastitis in sheep and goats; enteritis, pneumonia, erysipelas, and infectious arthritis in swine; and soft tissue infections in small animals. While tylosin may be one appropriate therapeutic choice in theory for the conditions listed above, there are many other antibiotics that may be preferable for treating a specific infection, and Tylosin will not be the first choice.

It is also used as a growth promoter for a variety of terrestrial and aquatic animals grown for human consumption(Hirsch et al. 1999)

What is the mechanism of action?

Like other macrolides, tylosin has a bacteriostatic effect on susceptible organisms, caused by inhibition of protein synthesis through binding to the 50S subunit of the bacterial ribosome.

Spectrum of Activity

Tylosin has a wide spectrum of activity against gram positive bacteria including Staphylococci, Streptococci, Corynebacteria, and Erysipelothrix. It has a much narrower gram negative spectrum of activity, but has been shown to be active against Campylobacter coli, and certain spirochaetes. It has also been shown to be extremely active against Mycoplasma species isolated from both mammalian and avian hosts.


Administration of tylosin should be avoided in animals with a known hypersensitivity to the product, or to other macrolides.

Oral administration can result in diarrhea and gastrointestinal disturbance. This is particularly true of horses, such that it can be fatal. Tylosin also has a foul taste that is difficult to disguise.

The injectable formulations of tylosin can cause pain, inflammation, and itchiness around the injection site.

Since tylosin has a relatively poor spectrum of activity against gram negative organisms, it may not be a sensible therapeutic choice in the treatment of infections caused by unknown, potentially unsusceptible organisms.

What are the side effects of Tylosin?

The most common side effects associated with Tylosin use are upset stomach, diarrhea and lack of appetite.

Lethargy and sleepiness have also been reported.

These side effects are usually temporary and mild and not a cause for concern.

The most common severe reaction in pets taking Tylosin is a possible allergic reaction. While most pets take the drug without any adverse effects whatsoever, some pets may be allergic to the ingredients in Tylosin.

Drug Interactions

Tylosin may increase digitalis blood levels and thus its toxicity, and may be antagonistic to chloramphenicol or lincosamides.

Colorimetric assays of serum ALT and AST may be falsely elevated by macrolide antibiotics.


Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.