Toltrazuril CAS NO 69004-03-1 Inquire about Toltrazuril
Tecoland supplies Toltrazuril bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Toltrazuril is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Toltrazuril?
Toltrazuril is a coccidiostat and triazinetrione derivative which decreases oocyst shedding and prevents clinical signs when dosed 10–15ppm in water. Toltrazuril and its major metabolite ponazuril (toltrazuril sulfone, Marquis) are triazine-based antiprotozoal drugs that have specific activity against apicomplexan coccidial infections.
What is Toltrazuril used for?
Toltrazuril has been used in animals to treat isosporiasis, toxoplasmosis, neosporosis, and equine protozoal meningoencephalitis. Triazine resistance has been described in coccidia from production animals. In dogs and cats, toltrazuril has been used to treat isosporiasis and hepatozoonosis, although infection may persist in some animals.
Mechanism of Action:
Toltrazuril appears to act on a plastid-like chloroplast organelle (the apicoplast) in apicomplexan protozoa, which may have originally been acquired from a green alga.35 This organelle contains a small circular genome and operates key biochemical pathways. Although its mechanism of action is unclear, triazines may inhibit metabolic enzymes or decrease pyrimidine synthesis within the apicoplast.
Toltrazuril Drug Interactions:
Toltrazuril is available in combination with the anthelmintic emodepside (Procox Oral Suspension for Dogs, Bayer Animal Health) for treatment of isosporiasis and roundworm infections in puppies over 2 weeks of age. The suspension contains 18 mg/mL of toltrazuril, and a single 9-mg/kg dose is recommended. Toltrazuril appeared to be as effective as trimethoprim -sulfadiazine -clindamycin -pyrimethamine for treatment of canine American hepatozoonosis. One dog with Hepatozoon canis infection recovered after treatment with toltrazuril and trimethoprim-sulfamethoxazole, but a toltrazuril and imidocarb combination did not offer benefit over treatment of H. canis infection with imidocarb alone. Dogs with H. canis infection respond clinically within 72 hours of starting treatment with toltrazuril
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Anecdotal reports exist of the use of ponazuril to treat Isospora spp. infections in dogs and cats, but its efficacy is unclear. Doses of ponazuril used have ranged from 20 to 50 mg/kg for 2 to 5 days. In one dog, ocular toxoplasmosis that was refractory to clindamycin resolved after treatment with ponazuril for 28 days.
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