Palonosetron HCl CAS NO 135729-62-3 Inquire about Palonosetron HCl 

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What is Palonosetron HCl?Palonosetron HCl

Palonosetron blocks the actions of chemicals in the body that may cause nausea and vomiting. Palonosetron is used to prevent nausea and vomiting associated with cancer chemotherapy. Palonosetron may also be used for purposes other than those listed in this medication guide.

How does Palonosetron HCl work?

Palonosetron is a selective serotonin subtype 3 (5-HT3) receptor antagonist with a strong binding affinity. 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. Cancer chemotherapy is associated with nausea and vomiting when serotonin is released from the enterochromaffin cells of the small intestine activates 5-HT3 receptors located on vagal afferents and activates the vomiting reflex. Palonosetron may also block ion channels involved in ventricular polarization may prolong action potential duration. The effect of palonosetron on blood pressure, heart rate, and ECG parameters including QTc were comparable to ondansetron and dolasetron in clinical trials.

Precautions

Do not take palonosetron without first talking to your doctor if you:

  • have an allergy or sensitivity to other similar medicines such as dolasetron, granisetron, or ondansetron
  • have low levels of potassium in the blood
  • have low levels of magnesium in the blood
  • are taking a diuretic
  • have a history of congenital QT syndrome
  • are taking a medicine to treat an irregular heartbeat.

Palonosetron may affect the heart, especially if you have any of the conditions or are taking any of the medicines listed above.

Palonosetron is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take palonosetron without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether palonosetron passes into breast milk. Do not take palonosetron without first talking to your doctor if you are breast-feeding a baby.

Drug Interactions

Do not take palonosetron without first talking to your doctor if you are taking any of the following medicines:

  • a diuretic such as furosemide, bumetanide, torsemide, chlorothiazide, hydrochlorothiazide, chlorthalidone, indapamide, metolazone, amiloride, spironolactone, triamterene, and others
  • a medicine to treat irregular heartbeats such as amiodarone, bepridil, disopyramide, sotalol, and others.

You may not be able to take palonosetron, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with palonosetron. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with palonosetron.

What are the side effects of Palonosetron HCl?

If you experience any of the following uncommon but serious side effects, stop taking palonosetron and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
  • irregular heartbeats.

Other, less serious side effects may be more likely to occur. Continue to take palonosetron and talk to your doctor if you experience:

  • headache;
  • fatigue or dizziness;
  • constipation; or
  • diarrhea.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What should I do if I miss a dose?

Palonosetron is intended to be used before administration of chemotherapy. Use of palonosetron during or following chemotherapy may not be effective. Contact your healthcare provider if a dose of palonosetron is missed.

If I overdose what should I do?

Seek emergency medical attention if an overdose is suspected. Symptoms of a palonosetron overdose are not well known but might include seizures, difficulty breathing, pale or blue colored skin, and collapse.

Storage

Palonosetron HCl should be Stored in a tightly sealed container away from heat, moisture, and direct light.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.