Moxidectin CAS NO 113507-06-5 Inquire about Moxidectin

Tecoland supplies Moxidectin bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Moxidectin is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Moxidectin?

Moxidectin (Milbemycin B) kills parasites, so is used for the prevention and control of heartworm and intestinal worms, and can be found in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. Application methods for moxidectin vary by treatment, and include oral, topical, and injectable solutions. Cydectin Pour On is a trade name for a formulation for use on cattle and red deer.

Moxidectin is a semisynthetic derivative of nemadectin which is produced by fermentation by Streptomyces cyano-griseus. This Streptomyces species was discovered in a soil sample from Australia in the late 1980s collected by an agronomist working for the American Cyanamid company.

What is the mechanism of action?

Moxidectin works in two ways: In common with other macrocyclic lactones, it displays a high affinity for the glutamate-gated ion channels specific to invertebrates. These glutamate-gated binding sites apparently occur in close proximity to GABA-gated sites, and the macrolide endectocides may increase GABA-gated sites as well.

Moxidectin binds to receptors on neuronal membranes of nematodes and myoneural junctions of arthropods. The chloride ion influx lowers cell membrane resistance and causes a hyperpolarization of the post-synaptic cells (Fig 4). This in turn makes neurotransmission more difficult and results in flaccid paralysis, death and/or expulsion of the parasite.

How to dose Moxidectin?

The recommended minimum dose for dogs is 10 mg/kg bodyweight imidacloprid and 2.5 mg/kg bodyweight moxidectin, which is equivalent to 0.1 ml/kg bodyweight of Advocate® for dogs. For cats, the recommended minimum dose is 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, which is equivalent to 0.1 ml/kg bodyweight of Advocate® for cats.

Reducing side effects

Giving the moxidectin product at the correct dosage and following the dosing instructions as specified by your veterinarian or the product packaging will greatly lessen the risk of your pet showing side effects.

Storage

The recommended storage temperature for moxidectin is 5±3°C.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.