Mezlocillin sodium CAS NO 59798-30-0 Inquire about Mezlocillin sodium
Tecoland supplies Mezlocillin sodium bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Mezlocillin sodium is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Mezlocillin?![Mezlocillin](https://tecoland.com/wp-content/uploads/2020/11/Mezlocillin.png)
Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria. Unlike most other extended spectrum penicillins, it is excreted by the liver, therefore it is useful for biliary tract infections, such as ascending cholangitis.
Mechanism of action
Main article: Beta-lactam antibiotic
Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.
Susceptible organisms
Gram-negative
- Bacteroides, including B. fragilis
- Enterobacter
- Escherichia coli
- Haemophilus influenzae
- Klebsiellaspecies
- Morganella morganii
- Neisseria gonorrhoeae
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Pseudomonas, including P. aeruginosa
- Serratia marcescens
Gram-positive
- Enterococcus faecalis
- Peptococcus
- Peptostreptococcus
Synthesis
Mezlocillin can be made in a variety of ways including reaction of ampicillin with chlorocarbamate 1 in the presence of triethylamine. Chlorocarbamate 1 itself is made from ethylenediamine by reaction with phosgene to form the cyclic urea followed by monoamide formation with methanesulfonyl chloride and then reaction of the other nitrogen atom with phosgene and trimethylsilylchloride.
The closely related analogue azlocillin is made in essentially the same manner as mezlocillin. but with omission of the methylation step.
Disclaimer:
Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.
External Link:
Wikipedia contributors. (2020a, October 7). Mezlocillin. Wikipedia. https://en.wikipedia.org/wiki/Mezlocillin