Lasalocid Sodium CAS NO 25999-20-6 Inquire about Lasalocid Sodium

Tecoland supplies Lasalocid Sodium bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Lasalocid Sodium is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Lasalocid?

Lasalocid is an antibacterial agent and a coccidiostat, which is produced by strains of Streptomyces lasaliensis. It is the drug in the feed additives called Bovatec and Avatec.Lasalocid is able to make neutral complexes with monovalent and divalent cations and transport them through apolar phase (including lipid bilayer membranes). It can also transport big organic cations like dopamine. Horses and dogs are very susceptible to the toxic effects of lasalocid, and it should never be administered to non-target species.

Mechanism of Action:

The mechanism of action of lasalocid and other ionophores has been extensively investigated and reported. Like other carboxylic polyether ionophores, lasalocid disturbs ionic homeostasis, leading to osmotic lysis of coccidia.

Pharmacokinetics:

Following oral administration to poultry species, lasalocid sodium is rapidly absorbed and detected in the peripheral circulation. Peak concentrations in blood are observed within two hours, with a half-life of three hours. Distribution is widespread and rapid with lasalocid detected in all edible tissues. Metabolism in each tissue is significant, with 5–7 unidentified polar metabolites produced. Excretion of the parent moiety and metabolites is rapid and primarily via the faeces.

Interaction:

Clinically important interactions between ionophore anticoccidials and the antibiotic tiamulin (and other antibiotics) are well known phenomena in chickens, turkeys and other species. Avoid concurrent administration of lasalocid with tiamulin. Avoid concurrent administration of lasalocid with chloramphenicol.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.