Fluralaner CAS NO 864731-61-3 Inquire about Fluralaner 

Tecoland supplies Fluralaner bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Fluralaner is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Fluralaner

Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally or topically. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014 and Bravecto Plus as a topical treatment for cats in November 2019, with warnings about possible side effects in both species. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.

What is it used for

A veterinary medicine used to treat parasitic infestations in dogs and cats. It may be used:

  • to treat flea and tick infestations in dogs and cats;
  • as part of the management of flea allergy dermatitis (an allergic reaction to flea bites) in dogs and cats;
  • to treat demodectic and sarcoptic mange (skin infestation caused by two different mites) in dogs;
  • to reduce the risk of infection with the parasite Babesia canis canis transmitted by Dermacentor reticulatus ticks in dogs;
  • to treat ear mite infestations in cats.
How does is works

Fluralaner, acts as an ‘ectoparasiticide’. This means that it kills parasites that live on or in the skin or in the fur or ears of animals, such as fleas, ticks and mites. By killing D. reticulatus ticks, it also reduces the risk of infection with B. canis canis. In order to be exposed to the active substance, parasites must attach to the skin and commence feeding on the dog or cat.

Fluralaner kills fleas, ticks and mites that have ingested the dog’s or cat’s blood by acting on their nervous system. It blocks the normal movement of charged chloride particles (ions) in and out of nerve cells, especially those associated with gamma-aminobutyric acid (GABA) and glutamate, two substances that convey messages between nerves (neurotransmitters). This results in uncontrolled activity of the nervous system and the paralysis and death of the parasites. Fluralaner kills fleas before they can lay eggs and so helps to reduce contamination of the dogs’ or cats’ environment.

Toxicity

Oral fluralaner was more toxic than imidacloprid in all four house fly strains tested, 9- to 118-fold as toxic. Oral cross-resistance between imidacloprid and fluralaner was not detected, but imidacloprid resistance was not high in any of the tested strains. Fluralaner shows promise for control of horn flies and house flies.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.