Florfenicol CAS NO 73231-34-2 Inquire about Florfenicol

Tecoland supplies Florfenicol bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Florfenicol is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Florfenicol?

Florfenicol (marketed by Schering-Plough Animal Health under the trade name Nuflor) is a fluorinated synthetic analog of thiamphenicol.

In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus, for treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.

The use of florfenicol in horses, and likely in other equids, typically causes diarrhea. This has been anecdotally reported to progress to lethal cases of acute colitis. Therefore, use of this antimicrobial in the equine patient should be limited to cases in which other, safer, options are not available.

What is the mechanism of action?

Florfenicol is a bacteriostatic antibiotic that inhibits protein synthesis by binding to ribosomal subunits of susceptible bacteria, leading to the inhibition of peptidyl transferase{R-1; 13; 26} and thereby preventing the transfer of amino acids to growing peptide chains and subsequent protein formation. The bacterial receptor that is the site of action for florfenicol is considered to be the same as that for chloramphenicol and thiamphenicol.{R-13; 26} In the treatment of bovine respiratory disease, florfenicol may be considered bactericidal against some Mannheimia (Pasteurella) hemolytica and Pasteurella multocida when it is administered to achieve minimum inhibitory concentrations (MICs);{R-14} the minimum bactericidal concentrations (MBCs) are very close to the MICs.

How to dose Florfenicol?

Cattle

For treatment of BRD:

20 mg/kg IM (in neck muscle only); repeat in 48 hours. Alternatively, a single 40 mg/kg SubQ dose (in neck) may be used. Note: 20 mg/kg equates to 3 ml of the injection per 100 lb. of body weight. Do not exceed 10 ml per injection site. (Nuflor® Package Insert—Schering Plough)

Other actions/ effects

Florfenicol, like thiamphenicol, lacks the nitro group located on the chloramphenicol aromatic ring that has been associated with chloramphenicol-induced, non–dose-related,

irreversible aplastic anemia in people.{R-13; 24; 25} However, chloramphenicol and thiamphenicol also cause a dose-dependent, reversible bone marrow suppression in some animals and people{R-13} due to mitochondrial injury.{R-24} It is theoretically

possible that florfenicol could cause some dose-dependent, reversible bone marrow suppression, but it has not been clinically reported.

Storage

Store at 4° C.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.