Doramectin CAS NO 117704-25-3 Inquire about Doramectin

Tecoland supplies Doramectin bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Doramectin is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Doramectin?

Doramectin is an avermectin antiparasitic compound. Doramectin is isolated from fermentations from the soil organism Streptomyces avermitilis. The commercially available injectable solution is a colorless to pale yellow, sterile solution.

Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes: Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as an injection and as a 5 mg/ml topical solution.

Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufactured by Agrovet Market Animal Health) in an 1% Doramectin Long Acting Injectable Solution for cattle, sheep, swine[3] and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.

What is the mechanism of action?

The primary mode of action of doramectin is to affect chloride ion channel activity in the nervous system of nematodes and arthropods. Doramectin binds to receptors that increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods and causes paralysis and death of the parasites. Doramectin also enhances the release of gamma amino butyric acid (GABA) at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. Doramectin is generally not toxic to mammals as they do not have glutamategated chloride channels and these compounds do not readily cross the blood-brain barrier where mammalian GABA receptors occur.

Precautions of Doramectin

Do not use in other animal species as severe adverse reactions, including fatalities in dogs. Studies performed in breeding animals (bulls, and cows in early and late pregnancy), at a dose of 3X recommended had no effect on breeding performance.

Doramectin adverse effects

No listed adverse effects. Intramuscular injections may have a higher incidence of injection site blemishes at slaughter than do subcutaneous injections.

Storage of Doramectin

Stored below 86°F (30°C).

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.