Colistin Sulfate CAS NO 1264-72-8 Inquire about Colistin Sulfate

Tecoland supplies Colistin Sulfate bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Colistin Sulfate is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

General description

Chemical structure: peptide

Application

Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii. It has been used to study hephrotoxicity in the rat kidney, and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa.

Biochem/physiol Actions

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH.

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