Bleomycin HCl CAS NO 55658-47-4 Inquire about Bleomycin HCl

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What is Bleomycin?

Bleomycin is a cystotoxic antibiotic that is used as an anticancer agent in the therapy of testicular and germ cell cancers, Hodgkin disease, lymphomas and tumors of the head and neck.

How does Bleomycin work?

It works by slowing or stopping the growth of cancer cells. This medication may also be used to control the build-up of fluid around the lungs (pleural effusion) caused by tumors that have spread to the lungs. For this condition, bleomycin is placed in the space around the lungs through a chest tube.

What is Bleomycin used for?

Bleomycin is also used to treat Hodgkin’s disease and non-Hodgkin’s lymphoma, testicular cancer, and malignant pleural effusion (a build-up of fluid in the outer tissues of the lungs, caused by certain types of cancer).

Bleomycin Side effects:

Most people will not experience all of the bleomycin side effects listed. Bleomycin side effects are often predictable in terms of their onset and duration. Side effects are almost always reversible and will go away after treatment is complete. There are many options to help minimize or prevent side effects. There is no relationship between the presence or severity of side effects and the effectiveness of the medication. The side effects of bleomycin and their severity depend on how much of the drug is given, as well as how it is given. For example, high doses may produce more severe side effects. The following side effects are common (occurring in greater than 30%) for patients taking bleomycin:
• Fever and chills
• Skin reactions: redness, darkening of the skin, stretch marks on the skin, skin peeling, thickening of the skin, ulceration
• Nail thickening, nail banding
• Hair loss

These side effects are less common side effects (occurring in about 10-29%) for patients receiving bleomycin:
• Nausea and vomiting
• Poor appetite and weight loss.
• Mouth sores
• Phlebitis (inflammation of veins)
• Lung problems: pneumonitis, rarely pulmonary fibrosis
• Occasionally this can cause radiation recall effect. (see skin reactions)

Serious but uncommon side effects of bleomycin may include:
• Vascular effects leading to heart attack or stroke – potentially life-threatening conditions, or Raynaud’s phenomenon (a disorder of the small blood vessels that feed the skin, most commonly affecting the hands and feet).
• Severe allergic reaction (anaphylaxis) immediate or delayed for several hours. You will be monitored closely for any signs of allergic reaction (rash and flushing, lowered blood pressure, difficulty breathing).
• A severe reaction consisting of low blood pressure, confusion, fever, chills, and wheezing may occur in few patients treating lymphoma. If this is to occur, it will generally occur after the first or second dose.
• Pulmonary fibrosis is possible, particularly in the elderly or those receiving over 400 units during their lifetime. The incidence of lung problems increases with age and pre-existing lung conditions. There is a maximum lifetime dose of bleomycin. Your health care professional will monitor the amount of bleomycin you receive as well as your lung function during treatment.

Note all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.

Bleomycin Precautions:

Before starting bleomycin treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.

Do not receive any kind of immunization or vaccination without your doctor’s approval while taking bleomycin.

Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Bleomycin carries a pregnancy category D (may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).

For both men and women: Do not conceive a child (get pregnant) while taking bleomycin. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.

Bleomycin Interaction:

Some products that may interact with this drug include: brentuximab, digoxin, drugs that may harm the kidneys (for example, aminoglycosides such as gentamicin, cisplatin), phenytoin.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.