Atorvastatin Calcium CAS NO 134523-03-8 Inquire about Atorvastatin Calcium
Tecoland supplies Atorvastatin Calcium bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Atorvastatin Calcium is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Atorvastatin Calcium?
The calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation. Check for active clinical trials using this agent. (NCI Thesaurus).
What is Atorvastatin Calcium used for?
Atorvastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver.
Atorvastatin Calcium Side effects:
Lipitor (atorvastatin) is a statin used for the treatment of elevated total cholesterol, LDL, triglycerides, and to elevate HDL cholesterol. Side effects of Lipitor include:
• constipation
• diarrhea
• nausea
• fatigue
• gas
• heartburn
• headache
• mild muscle pain
Contact your doctor if you experience serious side effects of Lipitor including:
• muscle wasting and muscle breakdown (rhabdomyolysis)
• confusion or memory problems
• fever
• dark urine
• increased thirst or hunger
• drowsiness
• loss of appetite
• yellowing of the skin or eyes (jaundice)
Atorvastatin Calcium Warnings and Precautions:
Call your doctor right away if you have dark-colored urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness. These could be symptoms of a serious muscle problem called rhabdomyolysis, which can cause kidney problems.
Disclaimer:
Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.