Dydrogesterone CAS NO 152-62-5 Inquire about Dydrogesterone 

Tecoland supplies Dydrogesterone bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Dydrogesterone is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
Summary of Dydrogesterone

Dydrogesterone is a synthetic progesterone for menstrual cycle regulation, infertility treatment, prevention of miscarriage, and other conditions.
This is a synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.

Indication

Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.

Pharmacodynamics

Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Dydrogesterone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis.

Mechanism of action

Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.

Side Effects of Dydrogesterone

Common side effects of this drug are:

  • Migraines or headache, nausea (feeling sick)
  • Menstrual disorders (absent, painful or irregular periods, excess bleeding), breast pain and tenderness (sensitive to touch)
  • Depression, feeling dizzy, vomiting, liver problems (jaundice (yellow eyes), weakness, stomach pain, generalized discomfort), allergic skin reactions (rashes, itching, redness), weight gain
  • Severe allergic reactions causing swelling of face or throat causing difficulty to breathe and swallow, with or without rashes, itching, skin blisters and peeling
Toxicity

No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route.

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