Candesartan Cilexetil CAS NO 145040-37-5 Inquire about Candesartan Cilexetil 

Tecoland supplies Candesartan Cilexetil bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Candesartan Cilexetil is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Candesartan?Candesartan Cilexetil

Candesartan cilexetil (candesartan) is a drug used for treating high blood pressure (hypertension). It is in a class of drugs called angiotensin receptor blockers (ARBs) which includes losartan (Cozaar), valsartan (Diovan), and irbesartan (Avapro). Angiotensin, formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells surrounding blood vessels. Angiotensin’s attachment to the receptors causes the muscle cells to contract and the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure. Candesartan blocks the angiotensin receptor and therby prevents the action of angiotensin. As a result blood vessels expand and blood pressure is reduced. Candesartan was approved by the FDA in 1998.

What brand names are available for candesartan?

Atacand

Is candesartan available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for candesartan?

Yes

What are the side effects of candesartan?

The most common side effects of candesartan are:

  • headache,
  • dizziness,
  • fatigue, abdominal discomfort,
  • diarrhea, and
  • upper respiratory infections.

Other important side effects include:

  • hyperkalemia,
  • impotence,
  • reduced renal function, and
  • allergic reactions.

Rhabdomyolysis (inflammation and destruction of muscle) and angioedema (swelling of soft tissues including those of the throat and larynx) are rare but serious side effects of candesartan.

What is the dosage for candesartan?

The recommended dose range of candesartan for adults is 4 to 32 mg once daily. The usual starting dose for hypertension is 16 mg daily, and the starting dose for treating heart failure is 4 mg once daily. Doses may be doubled at 2 week intervals as tolerated by patients. The maximum dose is 32 mg daily.

Which drugs or supplements interact with candesartan?

Since ARBs can increase the concentrations of potassium in the blood, combining candesartan with other medications that can increase the concentration of potassium in the blood, such as hydrodiuril (Dyazide), spironolactone (Aldactone), and potassium supplements, may lead to dangerous increases in potassium blood levels. Combining candesartan or other ARBs with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. There have been reports that aspirin and other NSAIDs such as ibuprofen (Advil, Children’s Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ARBs. An increase in lithium (Eskolith, Lithobid) blood levels has been reported when lithium is combined with candesartan. Careful monitoring of lithium levels is recommended when candesartan and lithium are used concomitantly.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.

External Link

Wikipedia contributors. (2020, October 27). Candesartan. In Wikipedia, The Free Encyclopedia. Retrieved 22:11, February 11, 2021, from https://en.wikipedia.org/w/index.php?title=Candesartan&oldid=985672398