Edoxaban CAS NO 480449-70-5 Inquire about Edoxaban
Tecoland supplies Edoxaban bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Edoxaban is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Edoxaban?
Edoxaban is an oral anticoagulant drug which acts as a direct factor Xa inhibitor. Compared to warfarin it has fewer interactions with other medications. It was developed by Daiichi Sankyo and approved in July 2011 in Japan for prevention of venous thromboembolisms following lower-limb orthopedic surgery.
How does Edoxaban work?
Edoxaban helps prevent blood clots from forming by blocking the substance factor Xa. This is a blood clotting factor that’s needed for your blood to clot. When a drug like edoxaban blocks factor Xa, it decreases the amount of an enzyme called thrombin. Thrombin is a substance in your blood that’s needed to form clots.
What is Edoxaban used for?
Edoxaban is used to prevent serious blood clots from forming due to a certain irregular heartbeat (atrial fibrillation). It is also used to treat certain blood clots (such as in deep vein thrombosis-DVT or pulmonary embolus-PE).
Edoxaban Side effects:
The most common side effects that occur with edoxaban include:
• bleeding that takes longer to stop
• bruising more easily
• skin rash
• reduced liver function
• low red blood cell count (anemia). Symptoms may include:
o shortness of breath
o feeling very tired
o confusion
o fast heart rate and palpitations
o pale skin
o trouble concentrating
o headache
o chest pain
o cold hands and feet
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Serious bleeding: Symptoms can include:
• unexpected bleeding or bleeding that lasts a long time, such as:
• frequent nose bleeds
• unusual bleeding from your gums
• menstrual bleeding that’s heavier than normal
• bleeding that’s severe or that you can’t control
• red, pink, or brown-colored urine
• bright red or black-colored stools that look like tar
• coughing up blood or blood clots
• vomiting blood or vomit that looks like coffee grounds
• headaches, dizziness, or weakness
Spinal or epidural blood clots (hematoma). If you take this drug and also receive spinal anesthesia or have a spinal puncture, you’re at risk for spinal or epidural blood clots that may cause paralysis. Symptoms can include:
• back pain
• tingling or numbness in your legs and feet
• muscle weakness, especially in your legs and feet
• loss of control of your bowels or bladder (incontinence)
Edoxaban Precautions:
Before taking edoxaban, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, bleeding problems (such as bleeding of the stomach/intestines, bleeding in the brain), blood disorders (such as anemia, hemophilia, thrombocytopenia), recent major injury/surgery, frequent falls/injuries, stroke.
Before having surgery or any medical/dental procedures (especially spinal puncture or spinal/epidural anesthesia), tell your doctor or dentist that you are taking this medication and about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor or dentist may tell you to stop taking edoxaban before your surgery. Ask for specific instructions about stopping or starting this medication.
This medication may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages. Ask your doctor or pharmacist about how much alcohol you may safely drink.
This medication can cause bleeding. To lower the chance of getting cut, bruised, or injured, use great caution with sharp objects like safety razors and nail cutters. Use an electric razor when shaving and a soft toothbrush when brushing your teeth. Avoid activities such as contact sports. If you fall or injure yourself, especially if you hit your head, contact your doctor right away. Your doctor may need to check you for hidden bleeding that could be serious.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor before using this medication.
It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
Edoxaban Drug Interaction:
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug include: mifepristone, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, “blood thinners” such as warfarin, enoxaparin), certain antidepressants (including SSRIs such as fluoxetine, SNRIs such as desvenlafaxine/venlafaxine).
Other medications can affect the removal of edoxaban from your body, which may affect how edoxaban works. One example is rifampin, among others.
Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen or naproxen) that may increase your risk for bleeding if taken together with this medication. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.
Warnings:
Edoxaban can cause serious bleeding that can sometimes be fatal. This is because edoxaban is a blood thinner drug that reduces blood clotting. While taking this drug, you may bruise more easily and bleeding may take longer to stop.
Disclaimer:
Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.