Sugammadex Sodium CAS NO 343306-79-6 Inquire about Sugammadex Sodium

Tecoland supplies Sugammadex Sodium bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Sugammadex Sodium is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.

What is Sugammadex Sodium?

Sugammadex (Org 25969, trade name Bridion) is an agent for the reversal of neuromuscular block adeinduced by rocuronium and vecuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA). Sugammadex is used to reverse neuromuscular blockade after administration of the aminosterioidnon-depolarizing neuromuscular-blocking agents such as vecuronium or rocuronium.

Sugammadex Pharmacokinetics：

Sugammadex is a modified γ-cyclodextrin, with a lipophilic core and a hydrophilic periphery. This gamma cyclodextrin has been modified from its natural state by placing eight carboxyl thio ether groups at the sixth carbon positions. These extensions extend the cavity size allowing greater encapsulation of the rocuronium molecule. These negatively charged extensions electrostatically bind to the quaternary nitrogen of the target as well as contribute to the aqueous nature of the cyclodextrin. Sugammadex’s binding encapsulation of rocuronium is one of the strongest among cyclodextrins and their guest molecules. The rocuronium molecule (a modified steroid) bound within sugammadex’s lipophilic core, is rendered unavailable to bind to the acetylcholine receptor at the neuromuscular junction. Sugammadex, unlike neostigmine, does not inhibit acetylcholinesterase so cholinergic effects are not produced and co-administration of an antimuscarinic agent (glycopyrronium bromide or atropine) is not needed. Sugammadex might therefore be expected to have fewer adverse effects than the traditional reversal agents.

Efficacy:

A study was carried out in Europe looking at its suitability in rapid sequence induction. It found that sugammadex provides a rapid and dose-dependent reversal of neuromuscular blockade induced by high-dose rocuronium.

Tolerability:

Sugammadex was generally well tolerated in clinical trials in surgical patients or healthy volunteers. In pooled analyses, the tolerability profile of sugammadex was generally similar to that of placebo or neostigmine plus glycopyrrolate.

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