Fipronil CAS NO 120068-37-3 Inquire about Fipronil 

Tecoland supplies Fipronil bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Fipronil is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Fipronil?

Fipronil is a member of the phenyl pyrazole class of pesticides, which are principally chemicals with a herbicidal effect. Fipronil, however, acts as an insecticide with contact and stomach action. It is sparingly soluble in water; is stable at normal temperatures for one year but not stable in the presence of metal ions and is degraded by sunlight to produce a variety of metabolites one of which is extremely stable and is more toxic than the parent compound.

The history of Fipronil

Fipronil is an insecticide discovered and developed by Rhone-Poulenc between 1985-87 and placed on the market in 1993. Although effective against a variety of pests, there are concerns about its environmental and human health effects. Actively marketed in many industrialized and developing countries its, worldwide use is increasing.

Uses of Fipronil
  • Fipronil is used in the control and treatment of adult flea and tick infestations in dogs and cats.
  • Fipronil is used for treatment and control of chewing lice in dogs, puppies, kittens and cats
  • Fipronil aids in the control of sarcoptic mange infestations in dogs.
Fipronil mode of action

Fipronil is an extremely active molecule and is a potent disruptor of the insect central nervous system via the (-aminobutyric acid (GABA) regulated chloride channel. Despite the fact that the GABA channel is important in nerve transmission in both vertebrate and invertebrate animals, and that fipronil does bind to the GABA receptor in vertebrates, the binding is ‘less tight?which offers a degree of selectivity.

Fipronil side effects
  • While generally safe and effective when prescribed by a veterinarian, fipronil can cause side effects in some animals.
  • Fipronil should not be used in animals with known hypersensitivity or allergy to the drug.
  • not recommended for use in debilitated or geriatric animals.
  • not recommended for use in pregnant, debilitated, geriatric or nursing animals.
  • Fipronil is not recommended for use in kittens and puppies less than 8 weeks of age.
  • Fipronil may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with fipronil. Fipronil is a topical agent and temporary irritation at the site of application is possible.
  • Spotted areas may appear wet or oily for up to 24 hours.

Overdose is rare and no adverse effects have been reported even up to 5 times the dose.

Fipronil study on human health

There have been very few studies undertaken with human subjects, although human cells have been used in some carcinogenicity studies in which no adverse effects were detected. Fipronil has been classified as a Group C (Possible Human) Carcinogen based on an increase in thyroid follicular cell tumors in both sexes of the rat. In contrast, thyroid tumors induced by fipronil in rats are not considered of relevance to human health in the UK. However, concerns were raised about human exposure to Frontline spray treatment in 1996 leading to a denial of registration for the spray product. Commercial pet groomers and veterinarians were considered to be at risk from chronic exposure via inhalation and dermal absorption during the application of the spray, assuming that they may have to treat up to 20 large dogs per day.

What problems will the use of Fipronil arouse?

Climate -due to heat levels frequently encountered in the tropics, the likelihood of non-use of suitable protective clothing when applying fipronil or coming in contact with it shortly after application is increased. Due to possible human health hazards and known irritant characteristics of certain formulations, this is an area of concern.

Container disposal ?pesticide containers become attractive and valuable assets in materially poor communities and are frequently taken for use as storage vessels, etc. They are rarely adequately cleaned beforehand. Due to possible human health hazards, this is an area of concern.

Illiteracy-problems associated with inability to read label warnings during use may lead to increased human health risks.

Poor ecological knowledge ?where little is known of the ecology of habitats likely to be treated with fipronil, predictions cannot be made for effects on wildlife nor the implications for the structure and functioning of the ecosystem.

Unique, unusual and/or poorly known fauna ?the wide differences in toxicity of fipronil to different (even closely related) animals means that risk assessment for areas with unusual fauna cannot be predicted without extensive studies on locally occurring species. The need for incorporation of data on indigenous species in risk assessment in semi-arid regions, especially temporary ponds has been emphasized

Fipronil dosing Information

Medication should never be administered without first consulting your veterinarian.

The dose of fipronil is based on the weight of the dog. The topical spray is dosed for dogs and cats at 1.5 to 3 ml per pound of body weight. This correlates to 1 to 2 pumps per pound with the 250 ml bottle and 3 to 6 pumps per pound with the 100 ml bottle. Animals with long hair need the higher dose. As with the pipettes, the spray is applied once monthly.

The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.