Tecoland supplies Pemetrexed Disodium bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Pemetrexed Disodium is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
Pemetrexed disodium is an antifolate anticancer drug. It inhibits folate-dependent enzymes and inside cells it is converted to a metabolite which is a more potent inhibitor. Inhibiting the enzymes decreases the synthesis of nucleic acids and therefore reduces cell replication.
white or white crystalline powder; odorless, tasteless, easily absorb water; Solubility: freely soluble In Water,practically insoluble In chloroform, slightly soluable in Methanol; Specific Rotation:+10~16;Identification: (1)flame reaction with sodium salt;(2)The reaction time in the chromatogram of the assay preparation coorresponds to that in the chromatogram of the standard preparation, as obtained in the assay;(3)IR: should conform to the standard;PH: 6.5-8.0;Clear and color of solution:should conform to standard;Related substances:Individual impurity: 0.5%;tatal impurity: 1.0%; Ethanol, Methylene Chloride, ethyl acetate, N,N-dimethylformamide dimethyl acetal: Ethanol 0.5%, Methylene Chloride 0.06%, ethyl acetate 0.5%,N,N-dimethylformamide dimethyl acetal 0.088%;Water: 7.2%-10.2%;Assay:not less than 98.5%(on andydrous basid).
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