Tecoland supplies Mercaptopurine bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Mercaptopurine is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
Mercaptopurine (also called 6-mercaptopurine, 6-MP or its brand name Purinethol) is an immunosuppressive drug.
What is the mechanism of action?
6-MP ribonucleotide inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. This alters the synthesis and function of RNA and DNA. Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.
How to dose Mercaptopurine?
Take this medication by mouth with or without food with a full glass of water (8 ounces or 240 milliliters), usually once daily or as directed by your doctor. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. Doing so may help decrease the risk of side effects (e.g., kidney stones).
The dosage is based on your body weight, medical condition and response to treatment. Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.
Since this drug may be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. Properly discard any unused medication. Ask your pharmacist for details.
What are the side effects?
- fever, night sweats, weight loss, tiredness
- feeling full after eating only a small amount
- pain in your upper stomach that may spread to your shoulder
- easy bruising or bleeding, pale skin, feeling light-headed or short of breath, rapid heart rate
- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin)
Store at 20° to 25°C (68° to 77°F).
Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.