Linezolid  CAS NO 165800-03-3 Inquire about Linezolid  

Tecoland supplies Linezolid bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Linezolid is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Linezolid?Linezolid

Linezolid (li-NE-zoh-lid ) belongs to the family of medicines called antibiotics. Antibiotics are medicines used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Linezolid will not work for colds, or other virus infections.

Linezolid is used to treat infections of the blood, lungs, and skin. It may also be used for other conditions as determined by your doctor. It is given by injection or orally. It is used mainly for serious infection for which other medicines may not work.

How does Linezolid work?

Linezolid prevents bacteria from making proteins. This causes the bacteria to die. Linezolid has a different way of attacking bacteria, so they cannot develop a resistance to it. Linezolid is used to treat gram–positive organisms, especially those that are resistant to other antibiotics such as vancomycin.

How do I use Linezolid properly?
  • The liquid form of linezolid should be gently mixed by turning the bottle upside down 3 to 5 times before each dose. Do not shake this product.
  • Do not use after the expiration date on the label. The medicine may not work properly after that date. If you have any questions about this, check with your pharmacist.

To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days. Also, it works best when there is a constant amount in the blood. To help keep the amount constant, linezolid must be given on a regular schedule.

Precautions of Linezolid mode of action

Linezolid can lower the number of white blood cells in your blood temporarily, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions your doctor may ask you to take, especially when your blood count is low, to reduce the risk of infection or bleeding:

  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills.
  • Check with your doctor immediately if you notice any unusual bleeding or bruising.
  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
  • Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
  • Avoid contact sports or other situations where bruising or injury could occur.

When taken with certain foods or drinks, linezolid can cause an increase in blood pressure. To avoid this, do not eat large amounts of foods or drink beverages that have a high tyramine content (most common in foods that are aged, fermented, pickled, or smoked to increase their flavor, such as aged cheeses; air-dried, fermented, or smoked fish, meat, or poultry; sauerkraut; soy sauce; red wine; or tap beer. If a list of these foods and beverages is not given to you, ask your health care professional to provide one.

Linezolid pharmacokinetics

Linezolid is highly absorbed when administered orally, with a bioavailability of approximately 100 percent.15 This allows conversion from intravenous to oral therapy as soon as the patient is clinically stable; thus, it provides an advantage over comparative therapy that can be delivered only parenterally (i.e., vancomycin or quinupristin/dalfopristin [Synercid]). Linezolid is metabolized via hepatic oxidation without any cytochrome P-450 pathways. Elimination occurs through nonrenal, renal, and fecal mechanisms accounting for 65, 30, and 5 percent, respectively. The half-life is approximately five hours.15 Generally, the dosing interval for an antibiotic is three times the half-life–the dosing interval for linezolid is every 12 hours. Presently, no dosage adjustment is recommended for patients with renal insufficiency; however, linezolid is removed by hemodialysis and should be administered following dialysis.
Linezolid adverse effects

Adverse effects reported in clinical trials in more than 2 percent of patients include the following: rash, headache, diarrhea, nausea, vomiting, insomnia, constipation, and fever.15 The incidence was similar to the comparator groups: ceftriaxone, clarithromycin (Biaxin), dicloxacillin (Pathocil), oxacillin (Bactocill), and vancomycin.
Thrombocytopenia, defined as a decrease in platelet count below 75 percent of normal or baseline, was reported in 2.4 percent of patients receiving linezolid versus 1.5 percent in those in the comparator group.14 This effect may be associated with the higher dose or treatment duration exceeding two weeks. In addition, the FDA has recently reported cases of myelosuppression (anemia, leukopenia, and pancytopenia) warranting the monitoring of hematologic parameters and has issued a warning that myelosuppression is considered a potential adverse effect. The current recommendation is to monitor complete blood count status weekly, especially in patients receiving therapy longer than two weeks’ duration, those with preexisting myelosuppression, those receiving drugs that produce bone marrow suppression, and those with a chronic infection who have received other antibiotic therapy recently or concurrently. If myelosuppression occurs, then discontinuation of therapy should be considered.

Linezolid Special Conditions To Observe

Pregnancy

Linezolid has not been studied in pregnant women. Before taking this medicine, make sure your doctor knows if you are pregnant of if you may become pregnant.

Breast-feeding

It is not known whether linezolid passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of linezolid in children with use in other age groups.

Older adults

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to linezolid. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.