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Introduction
of Amorolfine
Amorolfine is a morpholine derivative which is used
topically as an antifungal agent. It has a broad spectrum of
activity, including dermatophytes, various filamentous and
dematiaceous fungi, yeasts and dimorphic fungi. Its activity
is fungicidal for most species. It penetrates into the nail
rapidly and achieves concentrations higher than the MICs
obtained for most of the fungi causing onychomycosis. Its
clearance is slow following topical application. Amorolfine
has been ineffective when administered orally to animals
with systemic fungal infections. This lack of activity may
be due to protein binding and/or rapid metabolism of the
drug.
The most significant advantage of nail lacquer formulation
is that it builds a non-water soluble film on the nail plate
which remains at the application site for a week. This film
acts as a depot for the drug [1809]. Cream, vaginal tablet
and spray formulations of amorolfine were once available but
no longer appear to be manufactured.
Side Effects of Amorolfine
Topical amorolfine is well-tolerated and minor local adverse
reactions are observed rarely. Burning sensation, dryness of
skin, scaling, itching, erythema and weeping have been
reported.
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Information on this page is provided for general
information purposes. You should not make a clinical treatment
decision based on information contained in this page without
consulting other references including the package insert of
the drug, textbooks and where relevant, expert opinion. We
cannot be held responsible for any errors you make in
administering drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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