Entecavir CAS NO 142217-69-4 Inquire about Entecavir 

Tecoland supplies Entecavir bulk active pharmaceutical ingredient (API) to the pharmaceutical industry. Our Entecavir is manufactured by cGMP compliant facility. Welcome to contact us for further details including current DMF status for the product and up to date regulatory status of the manufacturing facility. We look forward to assisting you with your research and development projects.
What is Entecavir?Entecavir

Entecavir is indicated for the treatment of chronic hepatitis B virus (HBV) infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

What is Entecavir used for?

Entecavir is used to treat chronic (long-term) hepatitis B infection (swelling of the liver caused by a virus) in people who show signs of liver damage. Entecavir is in a class of medications called nuceloside analogs. It works by decreasing the amount of hepatitis B virus (HBV) in the body. Entecavir does not cure hepatitis B and may not prevent complications of chronic hepatitis B such as cirrhosis of the liver or liver cancer. Entecavir does not prevent the spread of hepatitis B to other people.

How does Entecavir work?

Baraclude is a small-molecule guanosine nucleoside analog with selective activity against hepatitis B virus (HBV) polymerase. The drug is effectively phosporylated to the active triphosphate form, which competes with the natural substrate deoxyguanosine triphosphate, functionally inhibiting reverse transription actions of HBV polymerase, including base priming, negative strand DNA reverse transcription from RNA, and synthesis of the positive strand of HBV DNA. The drug produces only weak inhibition of normal cellular DNA polymerases and mitochondrial DNA polymerase.
Precautions Before Using Entecavir
Before taking entecavir,

  • tell your doctor and pharmacist if you are allergic to entecavir, or any of its ingredients, or any other medications. Ask your pharmacist for a list of ingredients in entecavir.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Neo-Rx, NeoFradin), paramomycin (Humatin), streptomycin, and tobramycin (Tobi, Nebcin); amphotericin B (Fungizone); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); medications to prevent rejection of a transplanted organ such as cyclosporine (Neoral, Sandimmune) or tacrolimus (Prograf); probenecid; or vancomycin Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have had a liver transplant (surgery to replace a diseased liver), or if you have or have ever had kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking entecavir, call your doctor. Do not breastfeed while you are taking entecavir.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking entecavir.
Entecavir side effects

Entecavir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • dizziness
  • diarrhea
  • heartburn
  • drowsiness
  • difficulty falling asleep or staying asleep

Some side effects can be serious. If you experience any of the symptoms listed in the IMPORTANT WARNING section, call your doctor immediately.

Entecavir may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

What should you do if you miss a dose of Entecavir?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Entecavir Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children and pets. Store it at room temperature and away from excess heat, light, and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed by flushing the tablets down the toilet or pouring the solution down the sink. Talk to your pharmacist about the proper disposal of your medication.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.